L-5-Methyltetrahydrofolate calcium, |151533-22-1|
Product Name:L-5-Methyltetrahydrofolate calcium
In short: LMF
MOQ: 100g
Alias:L-Methylfolate,L-Methyltetrahydrofolate
Molecular formula:C20H23CaN7O6
CAS No:151533-22-1
Mol. mass:497.51800
Standard: CP2005/BP2000/USP27
Appearance: White or light yellow amorphous or crystalline powder
Structural formula:
Characteristics: Levomefolic acid (INN) (also known as L-5-MTHF, L-methylfolate and L-5-methyltetrahydrofolate) is the primary biologically active form of folate used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine. It is also the form found in circulation and transported across membranes into tissues and across the blood-brain barrier. In the cell, L-methylfolate is used in the methylation of homocysteine to form methionine and tetrahydrofolate (THF). THF is the immediate acceptor of one carbon units for the synthesis of thymidine-DNA, purines (RNA and DNA) and methionine. The un-methylated form, folic acid (vitamin B9), is a synthetic form of folate, and must undergo enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR) to become biologically active.
Applications:Lack of folic acid may reduce the ability of cells to synthesize and repair DNA, folic acid supplementation may be a more favorable method of increasing folic acid lowering homocysteine levels and supporting normal cell proliferation, endothelial function, cardiovascular disease, and neurological function. In particular, supplementation of 5 MTHF during pregnancy has been shown to reduce the risk of neural tube defects and recurrence.
Brief Introduction to our mill:The company mainly manufacturesL-5-Methyltetrahydrofolate Since foundation, the company insists on the development road as 'technological innovation', and our products are sold well in North America, Western Europe, Southeast Asia, Central & South America and other more than 60 countries and regions. Adopting high-efficient modernized management model, the company has established market-oriented marketing system. The marketing system closely coordinates the R&D, production, quality management and other departments, thus it can provide domestic and international clients with overall, convenient and perfect technical services. Adhering to the enterprise tenet as 'technology as guide, survive on quality', insisting on the enterprise philosophy as 'solidarity, pursue excellence, keep improving, mutual development', we sincerely wish to cooperate with colleagues at home and abroad for mutualdevelopment.
Specification L-5-MTHF-Ca:
TEXTS | SPECIFICATIONS | RESULTS | ||
Water content | 6.0% to 17.0% | 14.2% | ||
Elemental impurities | B | ≤50ug/g | Not Detected | |
Pt | ≤10ug/g | Not Detected | ||
≤1.5ug/g | Not Detected | |||
Cd | ≤0.5ug/g | Not Detected | ||
Pb | ≤1.0ug/g | Not Detected | ||
Hg | ≤1.5ug/g | Not Detected | ||
Calcium | 7.0%-8.5% | 8.2% | ||
Chloride | ≤0.5% | ﹤0.5% | ||
4-aminobenzoyl-glutamic acid | ≤0.5% | 0.02% | ||
4a-hydroxy-5methyl tetrahydrofolic acid | ≤0.5% | 0.004% | ||
(6R) -Mefox | ≤1.0%(6R +6S) | 0.03% | ||
Tetrahydrofolic acid | ≤0.5% | Not Detected | ||
7,8 dihydrofolic acid | ≤0.5% | Not Detected | ||
Folic acid | ≤0.5% | Not Detected | ||
5,10-methylenetetrahydrofoflic acid | ≤0.5% | Not Detected | ||
5-methyltrahydropteroic acid | ≤0.5% | 0.02% | ||
Dimethyletrahyrofolic acid | ≤0.15% | 0.02% | ||
Individual unknown impurity | ≤0.10% | 0.03% | ||
Total impurities | ≤2.5% | 0.13% | ||
D-5-Methylfolate | ≤0.10% | 0.01% | ||
L-D-5-Methyltetrahydrofolate | 75.0%-79.0% | 78.9% | ||
Residual solvents | Ethanol | ≤5000ppm | 350ppm | |
Acetone | ≤5000ppm | 2ppm | ||
Isopropyl alcohol | ≤5000ppm | Not Detected | ||
Crystal form | Crystal C | Conforms | ||
Aerobic bacteria total count | ﹤1000cfu/g | 90cfu/g | ||
Mold and yeast count | ﹤100cfu/g | 80cfu/g | ||
Bile resistance of gram-negative bacteria | ﹤100cfu/g | Not Detected | ||
Microbial limitest test | E.coil | Not Detected | Not Detected | |
Staphylococcus aureus | Not Detected | Not Detected | ||
salmonella | Not Detected | Not Detected | ||
Assay of L-isomer(HPLC) | 95.0%-102.0% | 99.6% | ||
Packing:1kgs aluminum foil with PE bags.
Storage: Diaphragmation, tight storage, keep in a cool place.
Inquire:If you are interested in the above product, please kindly send your inquire e-mail to shali@shalichem.com. We will reply you ASAP!
